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PPL Antibody (C-term)

PPL Antibody (C-term)

Item no.	ABC-AP14171b-ev
Manufacturer	Abcepta
Amount	80 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applications	WB, IHC-P
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	PPL, KIAA0568, Periplakin, 190 kDa paraneoplastic pemphigus antigen, 195 kDa cornified envelope precursor protein
Available
Primary Accession	O60437
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq].
Bio References	Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) : Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) : Pyle, A.L., et al. Cardiovasc. Pathol. 19 (2), E13-E20 (2010) : Huang, Y., et al. Arch. Dermatol. Res. 301(10):703-709(2009) Boczonadi, V., et al. Exp. Cell Res. 313(16):3579-3591(2007)
Clonality	Polyclonal
Clone/Animal Names	RB18945
Gene ID	5493
Gene Name	PPL
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	PPL Antibody (C-term) (Cat. #AP14171b) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the PPL antibody detected the PPL protein (arrow).
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	PPL Antibody (C-term) (Cat. #AP14171b)immunohistochemistry analysis in formalin fixed and paraffin embedded human skin tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PPL Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Type image 2	IHC-P
Dilution image 2	1:10~50
Other Accession	NP_002696.3
Isotype	Rabbit Ig
Calculated MW	204747
Antigen Region	1301-1330
Antigen Source	HUMAN
Target/Specificity	This PPL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1301-1330 amino acids from the C-terminal region of human PPL.
NCBI Accession	NP_002696.3

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 80 ul

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Delivery expected until 9/4/2025

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