Bio Background |
VPS25, VPS36 (MIM 610903), and SNF8 (MIM 610904) formESCRT-II (endosomal sorting complex required for transport II), acomplex involved in endocytosis of ubiquitinated membrane proteins.VPS25, VPS36, and SNF8 are also associated in a multiproteincomplex with RNA polymerase II elongation factor (ELL; MIM 600284)(Slagsvold et al., 2005 [PubMed 15755741]; Kamura et al., 2001[PubMed 11278625]). |
Bio References |
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Im, Y.J., et al. Dev. Cell 17(2):234-243(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)Bowers, K., et al. J. Biol. Chem. 281(8):5094-5105(2006) |