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SPPL2B Antibody (Center)

SPPL2B Antibody (Center)

Manufacturer	Abcepta
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Specific against	other
Isotype	Ig
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applications	WB
Amount	200 ul
Host	Rabbit
Item no.	ABC-AP21609c
eClass 6.1	32160702
eClass 9.0	32160702
Available
Primary Accession	Q8TCT7
Application	WB
Bio Background	Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF- alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. May play a role in the regulation of innate and adaptive immunity.
Bio References	Irmler M., et al.Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases. Martoglio B., et al.Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases. Grigorenko A.P., et al.Biochemistry (Mosc.) 67:826-834(2002). Nagase T., et al.DNA Res. 7:143-150(2000). Grimwood J., et al.Nature 428:529-535(2004).
Clonality	polyclonal
Clone/Animal Names	RB53139
Gene ID	56928
Gene Name	SPPL2B {ECO:0000303\|PubMed:15385547, ECO:0000312\|HGNC:HGNC:30627}
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Anti-SPPL2B Antibody (Center)at 1:2000 dilution + human cerebellum lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 65 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Type image 1	WB
Dilution image 1	1:2000
Isotype	Rabbit Ig
Calculated MW	64644
Antigen Source	HUMAN
Target/Specificity	This SPPL2B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 196-229 amino acids from the Central region of human SPPL2B.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 200 ul

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Delivery expected until 7/4/2024