Phospho-CCND3(T283) Antibody

Synthetic Peptide

The protein encoded by this gene belongs to the highly
conserved cyclin family, whose members are characterized by a
dramatic periodicity in protein abundance through the cell cycle.
Cyclins function as regulators of CDK kinases. Different cyclins
exhibit distinct expression and degradation patterns which
contribute to the temporal coordination of each mitotic event. This
cyclin forms a complex with and functions as a regulatory subunit
of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S
transition. This protein has been shown to interact with and be
involved in the phosphorylation of tumor suppressor protein Rb. The
CDK4 activity associated with this cyclin was reported to be
necessary for cell cycle progression through G2 phase into mitosis
after UV radiation. Several transcript variants encoding different
isoforms have been found for this gene.

Polyclonal

896

Affinity Purified Rabbit Polyclonal Antibody (Pab)

Dot blot analysis of CCND3 Antibody (Phospho T283) Phospho-specific Pab (Cat. #AP3870a) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.

1:500

B, M, Rat

32520

This CCND3 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T283 of human CCND3.