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AF9 (MLLT3) Antibody (C-term K486)

AF9 (MLLT3) Antibody (C-term K486)

Item no.	ABC-AP6190a-ev-80ul
Manufacturer	Abcepta
Amount	80 ul
Category	Oncology Antibodies Hematology Leukemia Lymphoma Sarcoma Myelofibrosis Immunohistochemistry Western Blot Primary Antibodies Heart & Blood Cancer
Type	Antibody Polyclonal
Applications	Western Blot, Immunohistochemistry
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Protein AF-9, ALL1-fused gene from chromosome 9 protein, Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein, YEATS domain-containing protein 3, MLLT3, AF9, YEATS3
Available
Primary Accession	P42568
Other Accession	A2AM29
Antigen Type	Synthetic Peptide
Bio Background	The human AF9 gene is one of the most common fusion partner genes with the ALL1 gene at 11q23 (also called MLL), resulting in the t(9; 11)(p22; q23). The AF9 gene is more than 100 kb, and 2 patient breakpoint cluster regions (BCRs) have been identified; BCR1 is within intron 4, previously called site A, whereas BCR2 or site B spans introns 7 and 8. Several different structural elements have been identified in AF9, including a colocalizing in vivo DNA topo II cleavage site and an in vitro DNase I hypersensitive (DNase 1 HS) site in intron 7 in BCR2. Reversibility experiments demonstrated a religation of the topo II cleavage sites. In addition, 2 scaffold associated regions (SARs) are located centromeric to the topo II and DNase I HS cleavage sites and border breakpoint regions in 2 leukemic cells lines: SAR1 is located in intron 4, whereas SAR2 encompasses parts of exons 5-7. The patient breakpoint regions of AF9 share the same structural elements as the MLL BCR. A DNA breakage and repair model for nonhomologous recombination between MLL and its partner genes, particularly AF9, has been proposed.
Bio References	Iida, S., et al., Oncogene 8(11):3085-3092 (1993). Nakamura, T., et al., Proc. Natl. Acad. Sci. U.S.A. 90(10):4631-4635 (1993). Strissel, P. L., et al., Hum. Molec. Genet. 9: 1671-1679 (2000).
Gene ID	4300
Gene Name	MLLT3 {ECO:0000303\|PubMed:16001262, ECO:0000312\|HGNC:HGNC:7136}
Reactivity	H
Predicted	M
Calculated MW	63351
Antigen Region	471-502
Antigen Source	HUMAN
Target/Specificity	This AF9 (MLLT3) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 471-502 amino acids from the C-terminal region of human AF9 (MLLT3).
NCBI Accession	NP_004520.2

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Amount: 80 ul

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