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APP Antibody (N-term)

APP Antibody (N-term)

Item no.	ABC-AP6306A
Manufacturer	Abcepta
Amount	400 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applications	WB, FC, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	APP, A4, AD1, Amyloid beta A4 protein, ABPP, APPI, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II, N-APP, Soluble APP-alpha, Soluble APP-beta, C99, Beta-amyloid protein 42, Beta-APP42, CVAP, Beta-APP40, Beta-amyloid protein 40, PN-II, C31, C80, C83, AICD-50, AICD-57, AICD-59, AID(50), AID(57), AID(59), Amyloid intracellular domain 50, Amyloid intracellular domain 57, Amyloid intracellular domain 59, Gamma-CTF(50), Gamma-CTF(57), Gamma-CTF(59), S-APP-alpha
Available
Primary Accession	P05067
Antigen Type	Synthetic Peptide
Application	WB, FC, IHC-P
Bio Background	APP is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).
Bio References	Borroni, B., et al., Arch. Neurol. 60(12):1740-1744 (2003). Lleo, A., et al., J. Biol. Chem. 278(48):47370-47375 (2003). Zhou, Y., et al., Science 302(5648):1215-1217 (2003). Murakami, K., et al., J. Biol. Chem. 278(46):46179-46187 (2003). Kim, J.Y., et al., Biochem. Biophys. Res. Commun. 310(3):904-909 (2003).
Clonality	Polyclonal
Clone/Animal Names	RB5012
Gene ID	351
Gene Name	APP (HGNC:620)
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	M
Legend image 1	Anti-hAPP-H44 at 1：1000 dilution + Mouse brain whole tissue lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 87 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Type image 1	WB
Dilution image 1	1:2000
Legend image 2	Formalin-fixed and paraffin-embedded human brain with APP Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Type image 2	IHC-P
Dilution image 2	1:10~50
Legend image 3	Flow cytometric analysis of HepG2 cells using APP Antibody (N-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Type image 3	FC
Dilution image 3	1:10~50
Other Accession	P53601
Predicted	Pr
Isotype	Rabbit Ig
Calculated MW	86943
Antigen Region	29-61
Antigen Source	HUMAN
Target/Specificity	This APP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-61 amino acids from the N-terminal region of human APP.
NCBI Accession	NP_000475.1; NP_001129488.1; NP_001129601.1; NP_001129602.1; NP_001129603.1; NP_001191230.1; NP_001191231.1; NP_001191232.1; NP_958816.1; NP_958817.1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 11/6/2025

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