RELA Antibody (N-term)

Crown Antibodies; Primary Antibodies; Cancer; Cardiovascular; Cell Biology; Immunology; Metabolism; Microbiology; Neuroscience; Signal Transduction; Host-virus interaction; Inflammasome; RIG-l-like Receptor; Toll receptor signaling; Toll-Like Receptor; Toll-Like receptor signaling; B cell receptor signaling; Immune system process; T cell receptor signaling; Chemokine signaling; Inflammation mediated by chemokine and cytokine signaling; Apoptosis; Apoptosis signaling

NFKB1 (MIM 16411) or NFKB2 (MIM 16412) is bound to REL(MIM 16491), RELA, or RELB (MIM 64758) to form the NFKB complex. The p5 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 1648 or NFKBIB, MIM 64495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 6664, or IKBKB, MIM 63258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).

RB20786

Purified Rabbit Polyclonal Antibody (Pab)

C, X

HUMAN

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Synthetic Peptide