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REA (PHB2) Antibody (N-term)

REA (PHB2) Antibody (N-term)

Item no.	ABC-AP7270a
Manufacturer	Abcepta
Amount	400 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applications	WB, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	Prohibitin-2, D-prohibitin, B-cell receptor-associated protein BAP37, Repressor of estrogen receptor activity, PHB2 {ECO:0000312\|EMBL:AAH147661, ECO:0000312\|HGNC:HGNC:30306}
Available
Primary Accession	Q99623
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. This protein functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. It competes with NCOA1 for modulation of ER transcriptional activity. It is probably involved in regulating mitochondrial respiration activity and in aging.
Bio References	Takata, H., Curr. Biol. 17 (15), 1356-1361 (2007) Kasashima, K., J. Biol. Chem. 281 (47), 36401-36410 (2006)
Clonality	Polyclonal
Clone/Animal Names	RB10629
Gene ID	11331
Gene Name	PHB2 {ECO:0000312\|EMBL:AAH14766.1, ECO:0000312\|HGNC:HGNC:30306}
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of PHB2 (arrow) using rabbit polyclonal PHB2 Antibody (Human C-term) (Cat.#AP7270a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PHB2 gene (Lane 2) (Origene Technologies).
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with PHB2 Antibody (N-term) (Cat.#AP7270a), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Type image 2	IHC-P
Dilution image 2	1:10~50
Other Accession	Q5XIH7; O35129; Q5ZMN3; Q2HJ97; NP_009204
Predicted	B, C, M, Rat
Isotype	Rabbit Ig
Calculated MW	33296
Antigen Region	66-95
Antigen Source	HUMAN
Target/Specificity	This REA (PHB2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-95 amino acids from the N-terminal region of human REA (PHB2).
NCBI Accession	NP_001138303.1; NP_001254629.1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 11/6/2025

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