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VINC Antibody (N-term)

VINC Antibody (N-term)

Item no.	ABC-AP7426a-ev
Manufacturer	Abcepta
Amount	80 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applications	WB, IHC-P
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	Vinculin, VCL, Metavinculin, MV
Available
Primary Accession	P18206
Antigen Type	Synthetic Peptide
Application	WB, IHC-P
Bio Background	VINC is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia.
Bio References	Moiseyeva E.P., Weller P.A.J. Biol. Chem. 268:4318-4325(1993) Sun N., Critchley D.R., Paulin D.Biochem. J. 409:657-667(2008) Izard T., Evans G., Borgon R.A.Nature 427:171-175(2004)
Clonality	Polyclonal
Clone/Animal Names	RB15469
Gene ID	7414
Gene Name	VCL
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M, Rat
Legend image 1	Western blot analysis of anti-VINC Antibody (N-term) (Cat.#AP7426a) in K562 cell line lysates (35ug/lane). VINC (arrow) was detected using the purified Pab.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Western blot analysis of anti-VINC Antibody (N-term) (Cat.#AP7426a) in mouse lung tissue lysates (35ug/lane). VINC (arrow) was detected using the purified Pab.
Type image 2	WB
Dilution image 2	1:1000
Legend image 3	All lanes : Anti-VINC Antibody (N-term) at 1:2000 dilution Lane 1: RD whole cell lysates Lane 2: Hela whole cell lysates Lane 3: rat liver lysates Lane 4: human testis lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 124 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Type image 3	WB
Dilution image 3	1:2000
Legend image 4	Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with VINC antibody (N-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Type image 4	IHC-P
Dilution image 4	1:10~50
Other Accession	P85972; P26234; Q64727; P12003
Predicted	C, Pig
Isotype	Rabbit Ig
Calculated MW	123799
Antigen Region	12-39
Antigen Source	HUMAN
Target/Specificity	This VINC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-39 amino acids from the N-terminal region of human VINC.
NCBI Accession	NP_003364.1; NP_054706.1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 80 ul

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Delivery expected until 10/2/2025

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