Caspase-3 (CASP3) Antibody (Center)

Primary Antibodies; Antibody Collections; Cancer; Cell Biology; Metabolism; Neuroscience; Amyotrophic Lateral Sclerosis (ALS); Apoptosis; Apoptosis signaling

CASP3 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 1. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.

RB14696

Purified Rabbit Polyclonal Antibody (Pab)

31608

60-90

WB: 1:1000
WB: 1:1000
WB: 1:2000
IHC-P: 1:10~50
FC: 1:10~50