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PDGFRA Antibody (Y762)

PDGFRA Antibody (Y762)

Manufacturer	Abcepta
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Specific against	other
Isotype	Ig
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applications	WB, IHC-P
Amount	400 ul
Host	Rabbit
Item no.	ABC-AP7666F
eClass 6.1	32160702
eClass 9.0	32160702
Available
Primary Accession	P16234
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	PDGFRA is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.
Bio References	Wilczynski, S.P., et al., Hum. Pathol. 36(3):242-249 (2005). Hiwatari, M., et al., Leukemia 19(3):476-477 (2005). Debiec-Rychter, M., et al., Gastroenterology 128(2):270-279 (2005). Sakurai, S., et al., Hum. Pathol. 35(10):1223-1230 (2004). Subramanian, S., et al., Oncogene 23(47):7780-7790 (2004).
Clonality	Polyclonal
Clone/Animal Names	RB11109
Gene ID	5156
Gene Name	PDGFRA
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of PDGFRA (arrow) using rabbit polyclonal PDGFRA Antibody (Y762) (RB11109). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PDGFRA gene (Lane 2) (Origene Technologies).
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human prostata carcinoma tissue reacted with PDGFRA Antibody (Y762) (Cat.#AP7666f), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Type image 2	IHC-P
Dilution image 2	1:10~50
Other Accession	P26619; P20786; P26618; NP_006197
Predicted	M, Rat, X
Isotype	Rabbit Ig
Calculated MW	122670
Antigen Region	740-769
Antigen Source	HUMAN
Target/Specificity	This PDGFRA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 740-769 amino acids from human PDGFRA.
NCBI Accession	NP_006197.1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 7/5/2024