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APP-Y756 Antibody

APP-Y756 Antibody

Item no.	ABC-AP9053A
Manufacturer	Abcepta
Amount	400 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applications	WB
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	APP, A4, AD1, Amyloid beta A4 protein, ABPP, APPI, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II, N-APP, Soluble APP-alpha, Soluble APP-beta, C99, Beta-amyloid protein 42, Beta-APP42, CVAP, Beta-APP40, Beta-amyloid protein 40, PN-II, C31, C80, C83, AICD-50, AICD-57, AICD-59, AID(50), AID(57), AID(59), Amyloid intracellular domain 50, Amyloid intracellular domain 57, Amyloid intracellular domain 59, Gamma-CTF(50), Gamma-CTF(57), Gamma-CTF(59), S-APP-alpha
Available
Primary Accession	P05067
Antigen Type	Synthetic Peptide
Application	WB
Bio Background	APP is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).
Bio References	Blomqvist, M.E., et al., Neurobiol. Aging 26(6):795-802 (2005). Yoon, I.S., et al., J. Biol. Chem. 280(20):20140-20147 (2005). Chen, M., et al., Biochem. Biophys. Res. Commun. 330(3):714-721 (2005). Yamamoto, M., et al., Am. J. Pathol. 166(5):1475-1485 (2005). Moir, R.D., et al., J. Biol. Chem. 280(17):17458-17463 (2005).
Clonality	Polyclonal
Clone/Animal Names	RB7005
Gene ID	351
Gene Name	APP (HGNC:620)
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of APP-pY756 (Cat. #AP9053a) in T47D cell line lysates (35ug/lane). APP (arrow) was detected using the purified Pab.
Type image 1	WB
Dilution image 1	1:1000
Other Accession	P08592; P79307; P12023; P53601
Predicted	Pr, M, Pig, Rat
Isotype	Rabbit Ig
Calculated MW	86943
Antigen Region	735-763
Antigen Source	HUMAN
Target/Specificity	This APP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 735-763 amino acids from human APP.
NCBI Accession	NP_000475.1; NP_001129488.1; NP_001129601.1; NP_001129602.1; NP_001129603.1; NP_001191230.1; NP_001191231.1; NP_001191232.1; NP_958816.1; NP_958817.1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 11/6/2025

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