RBM35B Antibody

Q9H6T0

RBM35B Antibody: RBM35A, also known as ESRP2, is a mRNA splicing factor that with its related protein RBM35A (ESRP1) are coordinators of an epithelial cell-type-specific splicing program. Both RBM35B and RBM35A are involved in posttranscriptional regulation of a number of genes such as FGFR2, CD44, CTNND1, and ENAH by exerting a differential effect on protein translation via 5' UTRs of mRNAs, suggesting that these proteins are global regulators of an epithelial regulatory network. Loss of this global ESRP-regulated epithelial splicing programme induces the phenotypic changes in cell morphology that are observed during the epithelial-mesenchymal transition.

Polyclonal

ESRP2

Western blot analysis of RBM35B in human lung tissue lysate with RBM35B antibody at 1 µg/mL.

Immunohistochemistry of RBM35B in human lung tissue with RBM35B antibody at 5 µg/mL.

Immunofluorescence of RBM35B in human lung tissue cells with RBM35B antibody at 20 µg/mL.

NP_079215; 45935393

78401

ESRP2; RBM35B antibody is predicted to not cross-react with other RBM35/ESRP family members. At least three isoforms of RBM35B are known to exist; this antibody will detect all three.

RBM35B antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

RBM35B antibody can be used for detection of RBM35B by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.

RBM35B Antibody is supplied in PBS containing 0.02% sodium azide.