CCP110 Antibody

O43303

CCP110 Antibody: CCP110 is a centrosomal protein required for the centrosome to function as a microtubule organizing center and plays an essential role in centrosome duplication. It is a target of cyclin-dependent kinases (CDKs); disruption of CCP110 phosphorylation leads to unscheduled centrosome separation and polyploidy. CCP110 is also a target of SCF (Cyclin F) ubiquitin ligase complex, leading to its degradation, suggesting that this complex controls centrosome homeostasis and mitotic fidelity through CCP110 degradation. The centriolar kinesin Kif24 also interacts with CP110 and remodel microtubules and regulate ciliogenesis.

Polyclonal

CCP110

Immunofluorescence of MAGEA4 in human breast cancer tissue with MAGEA4 antibody at 20 µg/ml.

NP_001185951; 9738

113424

CCP110 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human CCP110.

The immunogen is located within the last 50 amino acids of CCP110.

CCP110 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

CCP110 antibody can be used for detection of CCP110 by Western blot at 1 μ g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ g/mL. For immunofluorescence start at 5 μ g/mL.

CCP110 Antibody is supplied in PBS containing 0.02% sodium azide.