Comparison

TPT1 Antibody

Item no. ABC-ASC11604
Manufacturer Abcepta
Amount 100 ug
Category
Type Antibody Primary
Applications WB, IF, ELISA, IHC-P
Specific against other
Host Rabbit
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Available
Primary Accession
P13693
Application
WB, IHC-P, IF, E
Bio Background
TPT1 Antibody: TPT1 (translationally controlled tumor protein 1) is a 23 kDa member of the TCTP family of calcium binding proteins. TPT1 is localized in the cytoplasm and widely expressed and serves as a transcriptional activator, calcium transporter, histamine inducer and antiapoptotic caspase 3 inhibitor. TPT1 is a cytokine-like molecule that causes the release of histamine, IL-4 and IL-13 from basophils as well as the secretion of IL-8 and a calcium response in eosinophils. TPT1 plays a pivotal role in allergic diseases and due to its wide distribution in brain, is thought to be involved in neurodegenerative disorders, such as Alzheimer’s disease and Down syndrome.
Bio References
MacDonald SM, Rafnar T, Langdon J, et al. Molecular identification of an IgE-dependent histamine-releasing factor. Science 1995; 269:688-90.
MacDonald SM. Human recombinant histamine-releasing factor. Int. Arch. Allergy Immunol. 1997; 113:187-9.
Sanchez JC, Schaller D, Ravier F, et al. Translationally controlled tumor protein: a protein identified in several nontumoral cells including erythrocytes. Electrophoresis 1997; 18:150-5.
Kuna P and Kaplan AP. Relationship of histamine-releasing factors and histamine-releasing inhibitory factors to chemokine group of cytokine. Allergy Asthma Proc. 1996; 17:5-11.
Clonality
Polyclonal
Gene ID
7178
Gene Name
TPT1
Reactivity
H, M, Rat
Legend image 1
Western blot analysis of TPT1 in human brain tissue lysate with TPT1 antibody at (A) 0.5 and (B) 1 µg/mL.
Type image 1
WB
Legend image 2
Immunohistochemistry of TPT1 in rat brain tissue with TPT1 antibody at 2.5 µg/ml.
Type image 2
IHC
Legend image 3
Immunofluorescence of TPT1 in rat brain tissue with TPT1 antibody at 20 µg/ml.
Type image 3
IF
Other Accession
NP_003286; 4507669
Isotype
IgG
Calculated MW
19595
Antigen Source
homo sapiens
Target/Specificity
TPT1;
Purification
TPT1 Antibody is affinity chromatography purified via peptide column.
Reconstitution & Storage
TPT1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
Antibody Form
Liquid
Application Notes
TPT1 antibody can be used for detection of TPT1 by Western blot at 0.5 - 1 µg/mL.
Positive Control
Human Brain Tissue Lysate;
Buffer
TPT1 Antibody is supplied in PBS containing 0.02% sodium azide.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 ug
Available: In stock
available

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