Human IL-33 protein

Cytokine

IL-33

Lyophilized Human IL-33 proteinshould be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.8% HSA or BSA). Please prevent freeze-thaw cycles.

Interleukin 33 (IL-33), also known as DVS27 or NF-HEV (Nuclear Factor from High Endothelial enules), is a proinflammatory protein and a chromatin-associated cytokine of the IL-1 family with high sequence and structural similarity to IL-1 and IL-18. IL-33 protein is expressed highly and rather selectively by high endothelial venule endothelial cells (HEVECs) in human tonsils, Peyers's patches, and lymph nodes. IL-33 protein has transcriptional regulatory properties, and the researchers suggested that IL-33 is a dual-function protein that might act both as a cytokine and as an intracellular nuclear factor. As a type 2 cytokines, IL-33 protein also plays a pivotal role in helminthic infection and allergic disorders.

Lyophilized from sterile 20 mM Tris , 50 mM NaCl, pH 5.0, 1 mM DTT, 1 mM EDTA.

Endotoxin: < 0.01 EU per μg of the protein as determined by the LAL method.

E. coli

C9orf26, DVS27, IL1F11, NF-HEV, NFEHEV, Interleukin-33, IL33