« Back
Home /
ATRX Antibody (monoclonal) (M01)

ATRX Antibody (monoclonal) (M01)

Item no.	ABC-AT1246a
Manufacturer	Abcepta
Amount	100 ug
Category	Oncology Neuroscience Aging & Neurological Disorders Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Lymphoma Sarcoma Western Blot ELISA Primary Antibodies Astrocytoma Immunostaining
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, ELISA
Clone	3C9
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1 Kappa
Citations	ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brain. Kernohan KD, et al. Dev Cell, 2010 Feb 16. PMID 20159591.Regulation of ICP0-null mutant herpes simplex virus type 1 infection by ND10 components ATRX and hDaxx. Lukashchuk V, et al. J Virol, 2010 Apr. PMID 20147399.ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells. Wong LH, et al. Genome Res, 2010 Mar. PMID 20110566.Strong relationship between NT-proXNP levels and cardiac output following cardiac surgery in neonates and infants. Breuer T, et al. Acta Anaesthesiol Scand, 2010 Apr. PMID 19919584.Partial ATRX gene duplication causes ATR-X syndrome. Cohn DM, et al. Am J Med Genet A, 2009 Oct. PMID 19764021.
NCBI	NP_000480.3,NP_612114.2
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Transcriptional regulator ATRX,ATP-dependent helicase ATRX,X-linked helicase II,X-linked nuclear protein,XNP,Znf-HX,ATRX,RAD54L,XH2
Similar products	RAD54L, ATRX, XNP, XH2, X-linked nuclear protein, Transcriptional regulator ATRX, ATP-dependent helicase ATRX, X-linked helicase II, Znf-HX
Available
Manufacturer - Targets	ATRX (NP_000480, 2311 a.a. ~ 2410 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Bio Background	The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
Clonality	Monoclonal
Gene Name	ATRX
Subtitle	Mouse monoclonal antibody raised against a partial recombinant ATRX.
Reactivity	H
Antigen Source	Human: ~~ Positive
Formulation	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Concentration	1 mg/ml
Dilution	WB: 1:500~1000 E
Org Accession	NP_000480
Gene Description	alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)
Gene Summary	The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
Antigen Type	Recombinant Protein

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

ABC-AT1246a-datasheet.pdf

Request safety datasheet

Simple Order Order Subscription

Amount: 100 ug

available

Delivery expected until 1/1/2026

Express Delivery: Save 23 days

Compare

Add to wishlist

Get an offer