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BIRC5 Antibody (monoclonal) (M01)

BIRC5 Antibody (monoclonal) (M01)

Item no.	ABC-AT1299a
Manufacturer	Abcepta
Amount	100 ug
Category	Oncology Neuroscience Neural Lineage Markers Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Melanoma Cell Biology Cell Status Immunoprecipitation Western Blot ELISA Immunofluorescence Autophagy Primary Antibodies Immunostaining Neuronal Cell Markers
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, IF, IP, ELISA
Clone	5B10
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2a Kappa
Citations	1.Survivin expression induced by endothelin-1 promotes myofibroblast resistance to apoptosis.Horowitz JC, Ajayi IO, Kulasekaran P, Rogers DS, White JB, Townsend SK, White ES, Nho RS, Higgins PD, Huang SK, Sisson TH.Int J Biochem Cell Biol. 2011 Oct 25.2.The Closely Related RNA helicases, UAP56 and URH49, Preferentially Form Distinct mRNA Export Machineries and Coordinately Regulate Mitotic Progression.Yamazaki T, Fujiwara N, Yukinaga H, Ebisuya M, Shiki T, Kurihara T, Kioka N, Kambe T, Nagao M, Nishida E, Masuda S.Mol Biol Cell. 2010 Aug 15;21(16):2953-65. Epub 2010 Jun 23.
NCBI	NP_001012270.1,NP_001012271.1,NP_001159.2
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Baculoviral IAP repeat-containing protein 5,Apoptosis inhibitor 4,Apoptosis inhibitor survivin,BIRC5,API4,IAP4
Similar products	BIRC5, Baculoviral IAP repeat-containing protein 5, Apoptosis inhibitor 4, Apoptosis inhibitor survivin, API4, IAP4
Available
Manufacturer - Targets	BIRC5 (NP_001159, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Bio Background	This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of this gene's expression. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined.
Clonality	Monoclonal
Gene Name	BIRC5
Subtitle	Mouse monoclonal antibody raised against a partial recombinant BIRC5.
Reactivity	H
Antigen Source	Human: ~~ Positive
Formulation	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Concentration	0.38mg/ml; 0.5mg/ml
Dilution	IF IP WB: 1:500~1000 WB: 1:500~1000 WB: 1:500~1000
Org Accession	NP_001159
Gene Description	baculoviral IAP repeat-containing 5
Gene Summary	This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of this gene' s expression. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq
Antigen Type	Recombinant Protein

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Amount: 100 ug

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Delivery expected until 1/1/2026

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