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CA8 Antibody (monoclonal) (M01)

CA8 Antibody (monoclonal) (M01)

Item no.	ABC-AT1359a
Manufacturer	Abcepta
Amount	100 ug
Category	Neuroscience Targets for Rodent Neurosciences Antibodies Western Blot ELISA Primary Antibodies Immunostaining
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, ELISA
Clone	1F7
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG3 Kappa
Citations	CA8 mutations cause a novel syndrome characterized by ataxia and mild mental retardation with predisposition to quadrupedal gait. T?rkmen S, et al. PLoS Genet, 2009 May. PMID 19461874.Crystal structure of human carbonic anhydrase-related protein VIII reveals the basis for catalytic silencing. Picaud SS, et al. Proteins, 2009 Aug 1. PMID 19360879.Nucleotide variations in genes encoding carbonic anhydrase 8 and 10 associated with femoral bone mineral density in Japanese female with osteoporosis. Mori S, et al. J Bone Miner Metab, 2009. PMID 19172221.Carbonic anhydrase-related protein VIII promotes colon cancer cell growth. Nishikata M, et al. Mol Carcinog, 2007 Mar. PMID 17219437.A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070.
NCBI	NP_004047.3
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Carbonic anhydrase-related protein,CARP,Carbonic anhydrase VIII,CA-VIII,CA8,CALS
Similar products	CA8, CARP, CA-VIII, CALS, Carbonic anhydrase VIII, Carbonic anhydrase-related protein
Available
Manufacturer - Targets	CA8 (NP_004047, 40 a.a. ~ 139 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Bio Background	The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form.
Clonality	Monoclonal
Gene Name	CA8
Subtitle	Mouse monoclonal antibody raised against a partial recombinant CA8.
Reactivity	H
Antigen Source	Human: ~~ Positive
Formulation	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Dilution	WB: 1:500~1000 E
Org Accession	NP_004047
Gene Description	carbonic anhydrase VIII
Gene Summary	The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. [provided by RefSeq
Antigen Type	Recombinant Protein

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 1/1/2026

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