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HIP1 Antibody (monoclonal) (M01)

HIP1 Antibody (monoclonal) (M01)

Item no.	ABC-AT2370a
Manufacturer	Abcepta
Amount	100 ug
Category	Oncology Neuroscience Aging & Neurological Disorders Antibodies By Cell Type Carcinoma Hematology Leukemia Immunohistochemistry Immunoprecipitation Western Blot ELISA Primary Antibodies Immunostaining
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, IP, IHC, ELISA
Clone	1F12
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2a Kappa
Citations	Accommodation of structural rearrangements in the huntingtin-interacting protein 1 coiled-coil domain. Wilbur JD, et al. Acta Crystallogr D Biol Crystallogr, 2010 Mar. PMID 20179344.Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Han JW, et al. Nat Genet, 2009 Nov. PMID 19838193.HIP1 exhibits an early recruitment and a late stage function in the maturation of coated pits. Gottfried I, et al. Cell Mol Life Sci, 2009 Sep. PMID 19626275.Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain. Wilbur JD, et al. J Biol Chem, 2008 Nov 21. PMID 18790740.Crystal structure at 2.8 A of Huntingtin-interacting protein 1 (HIP1) coiled-coil domain reveals a charged surface suitable for HIP1 protein interactor (HIPPI). Niu Q, et al. J Mol Biol, 2008 Feb 1. PMID 18155047.
NCBI	NP_001230127.1,NP_005329.3
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Huntingtin-interacting protein 1,HIP-1,Huntingtin-interacting protein I,HIP-I,HIP1
Similar products	HIP1, HIP-1, HIP-I, Huntingtin-interacting protein 1, Huntingtin-interacting protein I
Available
Manufacturer - Targets	HIP1 (NP_005329, 928 a.a. ~ 1037 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Bio Background	The product of this gene is a membrane-associated protein that colocalizes with huntingtin. This protein has similarities to cytoskeleton proteins and its interaction with huntingtin is thought to play a functional role in the cell filament network. Loss of normal huntingtin-HIP1 interaction in Huntington disease may contribute to a defect in membrane-cytoskeletal integrity in the brain. This gene could help in the understanding of the normal function of huntingtin and also the pathogenesis of Huntington disease. It also has been implicated in the pathogenesis of hematopoietic malignancies. An alternative splice variant of this gene has been described but its full length sequence has not been determined.
Clonality	Monoclonal
Gene Name	HIP1
Subtitle	Mouse monoclonal antibody raised against a partial recombinant HIP1.
Reactivity	H
Antigen Source	Human: ~~ Positive
Formulation	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Dilution	IP WB: 1:500~1000 WB: 1:500~1000 WB: 1:500~1000 IHC
Org Accession	NP_005329
Gene Description	huntingtin interacting protein 1
Gene Summary	The product of this gene is a membrane-associated protein that colocalizes with huntingtin. This protein has similarities to cytoskeleton proteins and its interaction with huntingtin is thought to play a functional role in the cell filament network. Loss of normal huntingtin-HIP1 interaction in Huntington disease may contribute to a defect in membrane-cytoskeletal integrity in the brain. This gene could help in the understanding of the normal function of huntingtin and also the pathogenesis of Huntington disease. It also has been implicated in the pathogenesis of hematopoietic malignancies. An alternative splice variant of this gene has been described but its full length sequence has not been determined. [provided by RefSeq
Antigen Type	Recombinant Protein

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 1/1/2026

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