« Back
Home /
HTRA2 Antibody (monoclonal) (M03)

HTRA2 Antibody (monoclonal) (M03)

Item no.	ABC-AT2459a
Manufacturer	Abcepta
Amount	100 ug
Category	Neuroscience Aging & Neurological Disorders Antibodies Western Blot ELISA Immunofluorescence Primary Antibodies Immunostaining
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, IF, ELISA
Clone	3G5
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1 Kappa
Citations	The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawal. Vande Walle L, et al. Cell Res, 2010 Apr. PMID 20125124.The Wilms' tumor suppressor protein WT1 is processed by the serine protease HtrA2/Omi. Hartkamp J, et al. Mol Cell, 2010 Jan 29. PMID 20122399.A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease. Kr?ger R, et al. Neurobiol Aging, 2009 Dec 23. PMID 20036034.Mitochondrial quality control: insights on how Parkinson's disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis. Dagda RK, et al. J Bioenerg Biomembr, 2009 Dec. PMID 20012177.Novel mitochondrial substrates of omi indicate a new regulatory role in neurodegenerative disorders. Johnson F, et al. PLoS One, 2009 Sep 18. PMID 19763263.
NCBI	NP_037379.1,NP_659540.1
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Serine protease HTRA2,mitochondrial,High temperature requirement protein A2,HtrA2,Omi stress-regulated endoprotease,Serine protease 25,Serine proteinase OMI,HTRA2,OMI,PRSS25
Similar products	HtrA2, OMI, HTRA2, mitochondrial, PRSS25, Serine protease HTRA2, High temperature requirement protein A2, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI
Available
Manufacturer - Targets	HTRA2 (AAH00096, 359 a.a. ~ 458 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Bio Background	This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.
Clonality	Monoclonal
Gene Name	HTRA2
Subtitle	Mouse monoclonal antibody raised against a partial recombinant HTRA2.
Reactivity	H
Antigen Source	Human: ~~ Positive
Formulation	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Concentration	0.5mg/ml
Dilution	IF WB: 1:500~1000 WB: 1:500~1000 E
Org Accession	AAH00096
Gene Description	HtrA serine peptidase 2
Gene Summary	This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined. [provided by RefSeq
Antigen Type	Recombinant Protein

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

ABC-AT2459a-datasheet.pdf

Request safety datasheet

Simple Order Order Subscription

Amount: 100 ug

available

Delivery expected until 1/1/2026

Express Delivery: Save 23 days

Compare

Add to wishlist

Get an offer