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HMGCL Antibody (monoclonal) (M01)

HMGCL Antibody (monoclonal) (M01)

Manufacturer	Abcepta
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Specific against	other
Clone	4F4-D1
Format	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Applications	WB
Amount	100 ug
Host	Mouse
Item no.	ABC-AT2388a
eClass 6.1	32160702
eClass 9.0	32160702
Available
Primary Accession	P35914
Antigen Type	Recombinant Protein
Application	WB
Bio Background	The protein encoded by this gene belongs to the HMG-CoA lyase family. It is a mitochondrial enzyme that catalyzes the final step of leucine degradation and plays a key role in ketone body formation. Mutations in this gene are associated with HMG-CoA lyase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Bio References	1.Characterization of a novel HMG-CoA Lyase enzyme with a dual location in endoplasmic reticulum and cytosol.Arnedo M, Menao S, Puisac B, Teresa-Rodrigo ME, Gil-Rodriguez MC, Lopez-Vinas E, Gomez-Puertas P, Casals N, Casale CH, Hegardt FG, Pie J.J Lipid Res. 2012 Jul 30.2.Differential HMG-CoA lyase expression in human tissues provides clues about 3-hydroxy-3-methylglutaric aciduria.Puisac B, Arnedo M, Casale CH, Ribate MP, Castiella T, Ramos FJ, Ribes A, Perez-Cerda C, Casals N, Hegardt FG, Pie J.J Inherit Metab Dis. 2010 Aug; 33(4):405-10. Epub 2010 Jun 8.
Clonality	Monoclonal
Gene ID	3155
Gene Name	HMGCL
Subtitle	Mouse monoclonal antibody raised against a full length recombinant HMGCL.
Reactivity	H
Legend image 1	Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (61.49 KDa) .
Type image 1	WB
Dilution image 1	1:500~1000
Legend image 2	Western Blot analysis of HMGCL expression in transfected 293T cell line by HMGCL monoclonal antibody (M01), clone 4F4-D1. Lane 1: HMGCL transfected lysate(34.4 KDa). Lane 2: Non-transfected lysate.
Type image 2	WB
Dilution image 2	1:500~1000
Other Accession	BC010570
Isotype	IgG2a kappa
Antigen Source	Human: ~~ Positive
Target/Specificity	HMGCL (AAH10570, 1 a.a. ~ 325 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
NCBI Accession	NP_000182.2; NP_001159531.1
	Clone: 4F4-D1
Org Accession	AAH10570
Gene Description	3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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ABC-AT2388a-datasheet.pdf

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Amount: 100 ug

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Delivery expected until 7/4/2024