PPARD Antibody (monoclonal) (M03)

Item no.	ABC-AT3395a
Manufacturer	Abcepta
Amount	100 ug
Category	Metabolism Diabetes Glucose Homeostasis Antibodies Western Blot ELISA Primary Antibodies Immunostaining
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, ELISA
Clone	1G4
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1 Kappa
Citations	Mitochondrial biogenesis related endurance genotype score and sports performance in athletes. Eynon N, et al. Mitochondrion, 2010 Jul 18. PMID 20647061.+294T/C polymorphism in the PPAR-delta gene is associated with risk of coronary artery disease in normolipidemic Tunisians. Jguirim-Souissi I, et al. Genet Mol Res, 2010 Jul 13. PMID 20645257.Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Polymorphisms in PPARD, PPARG and APM1 associated with four types of traditional Chinese medicine constitutions. Wu Y, et al. J Genet Genomics, 2010 Jun. PMID 20621019.Association of the CYBA, PPARGC1A, PPARG3, and PPARD gene variants with coronary artery disease and metabolic risk factors of coronary atherosclerosis in a Russian population. Nikitin AG, et al. Heart Vessels, 2010 May. PMID 20512451.
NCBI	NP_001165289.1,NP_001165290.1,NP_001165291.1,NP_006229.1,NP_803184.1
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Peroxisome proliferator-activated receptor delta,PPAR-delta,NUCI,Nuclear hormone receptor 1,NUC1,Nuclear receptor subfamily 1 group C member 2,Peroxisome proliferator-activated receptor beta,PPAR-beta,PPARD,NR1C2,PPARB
Similar products	PPAR-delta, PPARD, NR1C2, PPARB, Peroxisome proliferator-activated receptor delta, NUCI, Nuclear hormone receptor 1, Nuclear receptor subfamily 1 group C member 2, Peroxisome proliferator-activated receptor beta, PPAR-beta, NUC1
Available
Manufacturer - Targets	PPARD (NP_006229, 56 a.a. ~ 165 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Bio Background	This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants.
Clonality	Monoclonal
Gene Name	PPARD
Subtitle	Mouse monoclonal antibody raised against a partial recombinant PPARD.
Reactivity	H
Antigen Source	Human: ~~ Positive
Formulation	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Dilution	WB: 1:500~1000 WB: 1:500~1000 E
Org Accession	NP_006229
Gene Description	peroxisome proliferator-activated receptor delta
Gene Summary	This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. [provided by RefSeq
Antigen Type	Recombinant Protein

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 1/1/2026

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