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PTPN22 Antibody (monoclonal) (M01)

PTPN22 Antibody (monoclonal) (M01)

Manufacturer	Abcepta
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Specific against	other
Clone	4F6
Format	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Applications	WB, ELISA
Amount	100 ug
Host	Mouse
Item no.	ABC-AT3493a
eClass 6.1	32160702
eClass 9.0	32160702
Available
Primary Accession	Q9Y2R2
Antigen Type	Recombinant Protein
Application	WB, E
Bio Background	This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Bio References	Latent autoimmune diabetes in adults differs genetically from classical type 1 diabetes diagnosed after the age of 35 years. Andersen MK, et al. Diabetes Care, 2010 Sep. PMID 20805278.Functional polymorphisms of PTPN22 and FcgR genes in Tunisian patients with rheumatoid arthritis. Sfar I, et al. Arch Inst Pasteur Tunis, 2009. PMID 20707220.PTPN22 polymorphism is related to autoimmune disease risk in patients with Turner syndrome. Bianco B, et al. Scand J Immunol, 2010 Sep. PMID 20696024.Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Association of the protein tyrosine phosphatase nonreceptor 22 haplotypes with autoimmune thyroid disease in the Japanese population. Ban Y, et al. Thyroid, 2010 Aug. PMID 20615141.
Clonality	Monoclonal
Gene ID	26191
Gene Name	PTPN22
Subtitle	Mouse monoclonal antibody raised against a full length recombinant PTPN22.
Reactivity	H
Legend image 1	Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (45.43 KDa) .
Type image 1	WB
Dilution image 1	1:500~1000
Legend image 2	Western Blot analysis of PTPN22 expression in transfected 293T cell line by PTPN22 monoclonal antibody (M01), clone 4F6. Lane 1: PTPN22 transfected lysate(85.1 KDa). Lane 2: Non-transfected lysate.
Type image 2	WB
Dilution image 2	1:500~1000
Legend image 3	Western blot analysis of PTPN22 over-expressed 293 cell line, cotransfected with PTPN22 Validated Chimera RNAi ( (Cat # AT3493a )
Type image 3	WB
Dilution image 3	1:500~1000
Legend image 4	Detection limit for recombinant GST tagged PTPN22 is 1 ng/ml as a capture antibody.
Type image 4	E
Other Accession	BC017785
Isotype	IgG2a Kappa
Antigen Source	Human: ~~ Positive
Target/Specificity	PTPN22 (AAH17785, 1 a.a. ~ 179 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
NCBI Accession	NP_001180360.1; NP_036543.4; NP_057051.3
	Clone: 4F6
Org Accession	AAH17785
Gene Description	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Gene Summary	This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq

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Amount: 100 ug

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Delivery expected until 7/4/2024