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TCEB3 Antibody (monoclonal) (M02)

TCEB3 Antibody (monoclonal) (M02)

Manufacturer	Abcepta
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Specific against	other
Clone	1F3
Format	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Applications	WB, IF
Amount	100 ug
Host	Mouse
Item no.	ABC-AT4181a
eClass 6.1	32160702
eClass 9.0	32160702
Available
Primary Accession	Q14241
Antigen Type	Recombinant Protein
Application	WB, IF
Bio Background	This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.
Bio References	The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. Landa I, et al. PLoS Genet, 2009 Sep. PMID 19730683.Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Olsen JV, et al. Cell, 2006 Nov 3. PMID 17081983.The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414.Structural and functional insights into the B30.2/SPRY domain. Woo JS, et al. EMBO J, 2006 Mar 22. PMID 16498413.
Clonality	Monoclonal
Gene ID	6924
Gene Name	ELOA (HGNC:11620)
Subtitle	Mouse monoclonal antibody raised against a partial recombinant TCEB3.
Reactivity	H
Legend image 1	Immunofluorescence of monoclonal antibody to TCEB3 on HeLa cell. [antibody concentration 10 ug/ml]
Type image 1	IF
Legend image 2	Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (37.84 KDa) .
Type image 2	WB
Dilution image 2	1:500~1000
Legend image 3	TCEB3 monoclonal antibody (M02), clone 1F3 Western Blot analysis of TCEB3 expression in Hela S3 NE ( (Cat # AT4181a )
Type image 3	WB
Dilution image 3	1:500~1000
Legend image 4	Western Blot analysis of TCEB3 expression in transfected 293T cell line by TCEB3 monoclonal antibody (M02), clone 1F3. Lane 1: TCEB3 transfected lysate(87.2 KDa). Lane 2: Non-transfected lysate.
Type image 4	WB
Dilution image 4	1:500~1000
Other Accession	NM_003198
Isotype	IgG2a Kappa
Antigen Source	Human: ~~ Positive
Target/Specificity	TCEB3 (NP_003189, 81 a.a. ~ 190 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
NCBI Accession	NP_003189.2
	Clone: 1F3
Org Accession	NP_003189
Gene Description	transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)
Gene Summary	This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 7/4/2024