Comparison

Angiotensin Converting Enzyme 2 (ACE2) Antibody European Partner

Item no. abx109271
Manufacturer Abbexa
Amount 80 ul
Quantity options 400 ul 80 ul
Category
Type Antibody Primary
Format Liquid
Applications WB, FC, IHC, ELISA
Specific against Human (Homo sapiens)
Host Rabbit
Isotype IgG
Conjugate/Tag Unconjugated
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Angiotensin Converting Enzyme 2 (ACE2)
Similar products Angiotensin Converting Enzyme 2 (ACE2)
Available
Manufacturer - Category
Primary Antibodies
Manufacturer - Targets
Angiotensin Converting Enzyme 2 (ACE2)
Manufacturer - Conjugate / Tag
Unconjugated
Storage Conditions
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Molecular Weight
Calculated MW: 92.5 kDa
Description
ACE2 cDNA encodes a deduced 805-amino acid protein containing a potential 17-amino acid N-terminal signal peptide and a putative 22-amino acid C-terminal membrane anchor. It also possesses a zinc metalloprotease consensus sequence and a conserved glutamine residue that may function as a third zinc ligand. ACE2 is expressed predominantly in vascular endothelial cells of the heart and kidney. ACE converts angiotensin I to angiotensin II, ACE2 converts angiotensin I to angiotensin 1-9, which has 9 amino acids. Angiotensin II is a potent blood vessel constrictor, while angiotensin 1-9 does not impact blood vessels but is cleaved by ACE to a shorter peptide, angiotensin 1-7, which is a blood vessel dilator. Spike (S) proteins of coronaviruses, including the SARS coronavirus, bind with cellular receptors to mediate infection of target cells. ACE2 binds the S1 domain of the SARS coronavirus S protein. SARS coronavirus replicates efficiently on ACE2-transfected but not mock-transfected 293T cells. Anti-ACE2 but not anti-ACE1 antibody blocks viral replication on Vero E6 cells. It has been proposed that ACE2 is a functional receptor for SARS coronavirus.
Dry Ice
No
Buffer
PBS containing 0.09% sodium azide.
Clonality
Polyclonal
Gene Symbol
ACE2
Note
This product is for research use only.
Purification
Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
UniProt Entry Name
ACE2_HUMAN

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 80 ul
Available: In stock
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