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Interleukin-8 (IL-8)

Interleukin-8 (IL-8)

Manufacturer	Anogen
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Glucose Homeostasis Antibodies By Cell Type Carcinoma Western Blot ELISA Primary Antibodies Neutralization
Type	Antibody Polyclonal
Specific against	Human
Format	Purified
Applications	WB, ELISA, NT
Amount	1.0mg
Host	Chicken
Item no.	ANOG-AI60001
Targets	CXCL8
eClass 6.1	32160702
eClass 9.0	32160702
Available
Description	Chicken anti-human Interleukin-8 polyclonal antibody (IgY fraction).
Target Protein	Human IL-8
Immunogen	Highly purified recombinant human IL-8
Specificity	This antibody recognizes human Interleukin-8 (IL-8)
Purification	Protein G affinity purified
Species Reactivity	Human, others not tested
Cross Reactivity	This polyclonal antibody exhibits no detectable cross-reactivity with human serum albumin, bovine serum albumin, and other cytokines tested such as IL-1beta, IL-16, TNF-alpha, GM-CSF, MCSF, bFGF and MIP-1alpha.
Background	Interleukin 8 (IL-8), like IL-6, is secreted by macrophages and a variety of cells that express Toll-like receptors in response to the stimulation of pathogens. IL-8's primary function is to recruit neutrophils and other target cells through chemotaxis to the infected site to eliminate pathogens. IL-8 causes increased intracellular Ca2+, release of reactive oxygen species, and other physiological changes required for migration and phagocytosis. IL-8 is also known to promote angiogenesis.
Formulation	Lyophilized from a solution in 0.01M PBS, pH 7.0
Reconstitution	Double distilled water is recommended to adjust the final concentration to 1.00mg/mL
Application info	ELISA: The antibody when used at 2.6ng/mL can detect recombinant human IL-8 coated on ELISA plate.Neutralization: Total chicken IgY fraction at the concentration of 50 ug/mL showed 60% inhibition of 10ng/mL IL-8 induced IL8RB/293 cell migration Western Blot: The antibody, when used at concentration of 0.26 ug/mL will allow visualization of recombinant human IL-8.
Research Area	Cytokine, interleukin and chemotaxis
Storage	Store at -20C

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1.0mg

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Delivery expected until 6/17/2024