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IRS-1 (Ser794) polyclonal antibody

IRS-1 (Ser794) polyclonal antibody

Manufacturer	Bioworld Technology, Inc
Category	Neuroscience Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Regulation of Appetite Neural Adhesion Molecules Antibodies Western Blot Endocrine Regulation of Lipid Metabolism Primary Antibodies
Type	Antibody Primary
Specific against	Human
Applications	WB
Amount	50ul
Host	Rabbit
Item no.	AP0164-50
Targets	INS ;;CD220;;INSR;;IRS1
eClass 6.1	32160702
eClass 9.0	32160702
Available
Swiss-Prot	P35568
Application_all	WB: 1:2000ca.1:4000
Background	Insulin receptor substrate 1 (IRS-1) is one of the major substrates of the insulin receptor kinase. IRS-1 contains multiple tyrosine phosphorylation motifs that serve as docking sites for SH2-domain containing proteins that mediate the metabolic and growth-promoting functions of insulin. IRS-1 also contains over 30 potential serine/threonine phosphorylation sites. Ser307 of IRS-1 is phosphorylated by JNK and IKK while Ser789 is phosphorylated by SIK-2, a member of the AMPK family. The PKC and mTOR pathways mediate phosphorylation of IRS-1 at Ser612 and Ser636/639, respectively. Phosphorylation of IRS-1 at Ser1101 is mediated by PKCtheta and results in an inhibition of insulin signaling in the cell, suggesting a potential mechanism for insulin resistance in some models of obesity.
Product	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Purification And Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage And Stability	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Specificity	IRS-1 (Ser794) polyclonal antibody detects endogenous levels of IRS-1 protein.
BiowMW	ca. 180 kDa
Note	For research use only, not for use in diagnostic procedure.
Immunogen	Synthetic peptide, corresponding to amino acids 764-824 of Human IRS-1.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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