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NKX6.1 (Marker for Pancreatic and Duodenal Neuroendocrine Tumors) (NKX61/2561), CF594 conjugate, 0.1mg/mL

NKX6.1 (Marker for Pancreatic and Duodenal Neuroendocrine Tumors) (NKX61/2561), CF594 conjugate, 0.1mg/mL

Item no.	B-BNC942561-500
Manufacturer	Biotium
Amount	500 uL
Quantity options	100 uL 500 uL
Category	Oncology Metabolism Diabetes Glucose Homeostasis Antibodies By Cell Type Primary Antibodies
Type	Antibody Primary
Format	Liquid
Applications	IHC
Clone	NKX61/2561
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2c
Conjugate/Tag	CF594
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Homeobox protein NK-6 homolog A; Homeobox protein Nkx-6.1; NK homeo box, family 6, member A; NK homeobox (Drosophila), family 6, A; NK homeobox, family 6, A; NK6 homeobox 1; NK6 transcription factor homolog A; NK6 transcription factor related, locus 1; NK6 transcription factor related, locus 1 (Drosophila); NKX6-1; NKX6.1; NKX61; NKX61_HUMAN; NKX6A
Shipping Condition	Room temperature
Available
Manufacturer - Type	Primary
Manufacturer - Applications	IHC, FFPE (verified)
Manufacturer - Category	Antibodies
Manufacturer - Isotype	IgG2c, kappa
Manufacturer - Targets	NKX6.1
Manufacturer - Conjugate / Tag	CF594
Manufacturer - Host	Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Shipping Temperature	Room temperature
Storage Conditions	Store at 2 to 8°C\|Protect fluorescent conjugates from light
Molecular Weight	40-50 kDa
Manufacturer - Research Area	Developmental biology\|Endocrinology\|Transcription factors
Description	Members of the Nkx family of homeodomain proteins are key regulators of growth and development in several tissues, including brain, heart and pancreas. During neural development, sonic hedgehog (Shh) is known to control cell fate and mitogenesis, which is correlated with Shh dose-dependent expression of several genes, including Nkx-6.1. Specifically, Nkx-6.1 is responsible for cellular differentiation in the ventral neural tube and spinal meninges in response to Shh. In the pancreas, Nkx-6.1 is exclusively expressed in the islets of Langerhans in differentiating and mature B cells, which produce Insulin. The presence of Pdx-1 is required for the expression of Nkx-6.1 as well as other pancreatic B cell specific genes, including Insulin, Glut2 and IAPP. Subsequently, Nkx-6.1 binds to the DNA consensus sequence, TTAATTAC, to direct the repression of specific genes in B cells.Nkx6.1 is highly expressed in pancreatic and duodenal well-differentiated neuroendocrine tumors (WDNETS) and in metastatic WDNETS, is a highly specific marker of tumors of pancreatic origin. It has thus been suggested that Nkx6.1 is a useful inclusion into IHC panels for identifying primary sites of WDNETS.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Product origin	Animal
Ingredient of biological origin	Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Special handling for PI and label	Protect from light
Undated stability guarantee in PI	2 years
Stability at RT during shipping (protected from light)	Stable at room temperature or 37°C (98°F) for 7 days.
UNSPSC Commodity	41116161
UNSPSC Commodity Title	Primary and secondary antibodies for multiple methodology immunostaining detection application
Classified or regulated chemicals	0.05% sodium azide (CAS 26628-22-8)
Concentration	0.1 mg/mL
Storage buffer	PBS, 0.1% BSA, 0.05% azide
Dated shelf life printed on label	Guaranteed for at least 24 months from date of receipt when stored as recommended
Immunogen (Secondaries, for anti tag only)	Human full-length recombinant NKX6.1 protein
Clonality	Monoclonal
Regulatory Status	For research use only (RUO)
Human Gene Symbol	NKX6-1
Unigene	546270
Positive Control	Human fetal small intestine lysate or pancreas tissue.
Antibody target cellular localization	Nucleus
Cell tissue expression	Pancreatic beta cells
Validated in protein array	Monospecific
Antibody application notes	Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody\|Immunohistology (formalin): 1-2 ug/mL for 30 minutes at RT\|Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 minutes followed by cooling at RT for 20 minutes\|Optimal dilution for a specific application should be determined by user
Manufacturer - Synonym	Homeobox protein NK-6 homolog A, Homeobox protein Nkx-6.1, NK homeo box, family 6, member A, NK homeobox (Drosophila), family 6, A, NK homeobox, family 6, A, NK6 homeobox 1, NK6 transcription factor homolog A, NK6 transcription factor related, locus 1, NK6 transcription factor related, locus 1 (Drosophila), NKX6-1, NKX6.1, NKX61, NKX61_HUMAN, NKX6A
Manufacturer - Antibody Reactivity	NKX6.1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 uL

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Delivery expected until 9/25/2025

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