ZAP70 (Chronic Lymphocytic Leukemia Marker)(ZAP70/2047), 0.2mg/mL

Flow, intracellular (verified), IF (verified), IHC, FFPE (verified)

ZAP70

Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

Store at 2 to 8°C|Protect fluorescent conjugates from light

ZAP70 is a 70 kDa protein tyrosine kinase found in T-cells and natural killer cells. Control of this protein translation is via the IgVH gene. ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well. Anti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

Stable at room temperature or 37°C (98°F) for 7 days.

Primary and secondary antibodies for multiple methodologyimmunostaining detection application

0.2 mg/mL

Guaranteed for at least 24 months from date of receipt when stored as recommended

Monoclonal

ZAP70

Jurkat cells. Tonsil or lymph node.

Lymphocytes|NK cells|T-cells

Monospecific

Flow (intracellular) (verified)|IF (verified)|IHC (FFPE) (verified)

#2047