OX40 / CD134/ TNFRSF4 (Immuno-Oncology Target)(OX40/3108), 0.2mg/mL

Flow (verified)|IF (verified)|IHC, FFPE (verified)

IgG2c, kappa

Purified, with BSA

Store at 2 to 8°C|Protect fluorescent conjugates from light

ThisMAb recognizes a protein of 43 kDa, identified as OX40, which is also known as CD134. OX40 is a type I integral membrane glycoprotein and member of the tumor necrosis factor/nerve growth factor receptor (TNFR/NGFR) family. It is expressed on activated T lymphocytes, hematopoietic precursor cells and fibroblasts. It functions as a T cell co-stimulatory receptor when bound by OX40 Ligand/TNFSF4 that is expressed by antigen presenting cells. OX40 thereby plays roles in T-cell activation as well as the regulation of differentiation, proliferation or apoptosis of normal and malignant lymphoid cells. OX40 is upregulated at the sites of inflammation, especially in case of multiple sclerosis and psoriatic lesions. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

2 years

41116161

PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)

PBS, 0.05% BSA, 0.05% azide

Recombinant fragment of human OX40 (CD134) protein (around aa 59-205) (exact sequence is proprietary)

For research use only (RUO)

129780

Plasma membrane

CD134, |OX40|TNFRSF4