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Anti-Mitofusin 1 MFN1 Antibody Picoband® (monoclonal, 3H3)

Anti-Mitofusin 1 MFN1 Antibody Picoband® (monoclonal, 3H3)

Item no.	BOS-M02172-1
Manufacturer	Boster
Amount	100 ug/vial
Quantity options	100 ug/vial 10 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug
Category	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Neural Mitochondrial Function Molecular Targets for Neuroscience Antibodies By Cell Type Carcinoma Hematology Leukemia Lymphoma Western Blot Immunofluorescence Immunocytochemistry Cardiovascular Research Atherosclerosis Primary Antibodies Immunochemistry
Type	Antibody Monoclonal
Format	Lyophilized
Applications	WB, IF, ICC
Clone	3H3
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2b
Sensitivity	>5000 cells
Citations	1. Adams MD, Kerlavage AR, Fields C, Venter JC (Sep 1993). 3,400 new expressed sequence tags identify diversity of transcripts in human brain. Nat Genet 4 (3): 256–67. 2. Meeusen, S., McCaffery, J. M., Nunnari, J. Mitochondrial fusion intermediates revealed in vitro. Science 305: 1747-1752, 2004. 3. Santel, A., Fuller, M. T. Control of mitochondrial morphology by a human mitofusin. J. Cell Sci. 114: 867-874, 2001.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Fzo homolog antibody,Hfzo1 antibody,Hfzo2 antibody,MFN 1 antibody,Mfn1 antibody,MFN1_HUMAN antibody,Mitochondrial transmembrane GTPase Fzo 1 antibody,Mitochondrial transmembrane GTPase FZO 2 antibody,Mitochondrial transmembrane GTPaseFZO1B antibody,Mitofusin 1 antibody,Mitofusin-1 antibody,Mitofusin1 antibody,Putative transmembrane GTPase antibody,Transmembrane GTPase MFN1 antibody
Available
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular weight	84 kDa
Clonality	Monoclonal
Application Details	Western blot, 0.1-0.5μg/ml, Human Immunocytochemistry/Immunofluorescence, 2μg/ml, Human
Gene Name	MFN1
Gene Full Name	mitofusin 1
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	Mitofusin-1 is a protein that in humans is encoded by the MFN1 gene. It is an 80-90 kDa mitochondrial member of the dynamin family of molecules. It is ubiquitously expressed, and found in the outer mitochondrial membrane. The protein encoded by this gene is a mediator of mitochondrial fusion, and thereby contribute to the dynamic balance between fusion and fission that determines mitochondria morphology. MFN1 is known to form oligomers, either with itself or MFN-2, and to undergo ubiquitination by MARCH5. MFN-1 has two key domains. One is a coiled-coil region that mediates MFN-1: MFN-1/2 binding, and a second is a GTPase domain whose cleavage of GTP is necessary for membrane fusion. Overexpression of MFN1 caused perinuclear mitochondrial clustering.
Immunogen	A synthetic peptide corresponding to a sequence at the N-terminal of human Mitofusin 1, different from the related mouse and rat sequences by one amino acid.
Contents	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500μg/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Manufacturer - Research Category	Class I, Cytoskeleton, Cytoskeleton/ECM, Intermediate Filaments, Signal Transduction
Protein Name	Mitofusin-1
Protein Function	Essential transmembrane GTPase, which mediates mitochondrial fusion.Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission.MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.
Subcellular Localization	Mitochondrion outer membrane; Multi- pass membrane protein.
Description	Boster Bio Anti-Mitofusin 1 MFN1 Antibody Picoband® (monoclonal, 3H3) catalog # M02172-1. Tested in IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity	Ubiquitous.Expressed at slightly higher level in kidney and heart.Isoform 2 may be overexpressed in some tumors, such as lung cancers.
Manufacturer - Alias	Fzo homolog antibody\|Hfzo1 antibody\|Hfzo2 antibody\|MFN 1 antibody\|Mfn1 antibody\|MFN1_HUMAN antibody\|Mitochondrial transmembrane GTPase Fzo 1 antibody\|Mitochondrial transmembrane GTPase FZO 2 antibody\|Mitochondrial transmembrane GTPaseFZO1B antibody\|Mitofusin 1 antibody\|Mitofusin-1 antibody\|Mitofusin1 antibody\|Putative transmembrane GTPase antibody\|Transmembrane GTPase MFN1 antibody
Manufacturer - Cross Reactivity	No cross-reactivity with other proteins.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-M02172-1-datasheet.pdf

BOS-M02172-1-safety-datasheet.pdf