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HER3 polyclonal antibody

HER3 polyclonal antibody

Manufacturer	Bioworld Technology, Inc
Category	Neuroscience Neural Signaling Neural Adhesion Molecules Antibodies Cell Biology Cell Status Immunohistochemistry Western Blot Immunofluorescence Cardiovascular Research Myocardial Infarction Oxidative Stress Primary Antibodies
Type	Antibody Primary
Specific against	Human, Mouse
Applications	WB, IF, IHC
Amount	50ul
Host	Rabbit
Item no.	BS62274-50
Targets	EGFR;;ERBB3;;PIK3R1;;SKP2
eClass 6.1	32160702
eClass 9.0	32160702
Available
Swiss-Prot	P21860
Application_all	WB: 1:500ca.1:1000 IHC: 1:50ca.1:200
Background	The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Full length ErbB-3 is overexpressed in human mammary tumors. The ErbB-3 gene also produces several alternative variants, including a secreted form which negatively regulates heregulin stimulated ErbB activation. ErbB-3 heterodimerizes with Neu and binds heregulin in order to activate phosphoinositide (PI) 3-kinase. The recruitment and activation of PI 3-kinase occurs via its interaction with phosphorylated YXXM motifs in the carboxy terminus of ErbB-3.
Product	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification And Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage And Stability	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Specificity	HER3 polyclonal antibody detects endogenous levels of HER3 protein.
BiowMW	ca. 185 kDa
Note	For research use only, not for use in diagnostic procedure.
Immunogen	Synthetic peptide, corresponding to Human HER3.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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