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PINK1 (Phospho-S228) polyclonal antibody

PINK1 (Phospho-S228) polyclonal antibody

Manufacturer	Bioworld Technology, Inc
Category	Neuroscience Neuroinflammation Neural Mitochondrial Function Protein Aggregation, Clearance & Misfolding Antibodies Cell Biology Cell Status Western Blot Autophagy Primary Antibodies
Type	Antibody Primary
Specific against	Human, Mouse, Rat
Applications	WB
Amount	100ul
Host	Rabbit
Item no.	BS64545-100
Targets	PINK1
eClass 6.1	32160702
eClass 9.0	32160702
Available
Swiss-Prot	Q9BXM7
Application_all	WB: 1:500ca.1:1000 IHC: 1:50ca.1:200
Background	PTEN induced putative kinase 1, PINK1, is a mitochondrial serine/threonine kinase involved in the normal function and integrity of mitochondria, as well as in reduction of cytochrome c release from mitochondria. PINK1 phosphorylates Parkin and promotes its translocation to mitochondria. Research studies have shown that mutations in PINK1 are linked to autosomal recessive early onset Parkinson's disease, and are associated with loss of protective function, mitochondrial dysfunction, aggregation of alpha-synuclein, as well as proteasome dysfunction.
Product	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification And Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage And Stability	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Specificity	PINK1 (Phospho-S228) polyclonal antibody detects endogenous levels of PINK1 protein only when phosphorylated at Ser228.
BiowMW	ca. 60 kDa
Note	For research use only, not for use in diagnostic procedure.
Immunogen	Synthetic phosphopeptide derived from human PINK1 around the phosphorylation site of Serine 228.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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