Manufacturer |
Bioworld Technology, Inc
|
Category |
|
Type |
Antibody Primary |
Specific against |
Human, Mouse, Rat |
Applications |
WB, FC, IF, ICC |
Amount |
50ul |
Host |
Rabbit |
Item no. |
BS90062-50 |
Targets |
ANXA5;;CD142;;REG3A |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Available |
|
Alias |
CBP-I, PP4, PAP-I, VAC-alpha, ANXA5, Anchorin CII, Annexin 5, Annexin A5, Annexin V, Annexin-5, ANX A5, ANX5, ANXA5, ANXA5, Calphobindin I, CBP-I, Endonexin II, ENX2, Lipocortin V, PAP I, PAP-I, Placental anticoagulant protein 4, Placental anticoagulant p |
Swiss-Prot |
P08758(Human) P48036(Mouse) P14668(Rat) |
Application_all |
WB:1:1, 000 FC:1:50-1:100 ICC:1:100-1:500 |
Background |
The annexin family of calcium-binding proteins is composed of at least ten mammalian genes and is characterized by a conserved core domain, which binds phospholipids in a Ca2+-dependent manner, and a unique amino-terminal region, which may confer binding specificity. Annexin family members have been implicated as regulators of such diverse processes as ion flux, endocytosis and exocytosis, and cellular adhesion. For example, the crystal structure of Annexin III has suggested a hydrophilic amino-terminus with possible Ca2+ channel activity. Similarly, Annexin V has ion channel properties. Annexin IV, also referred to as endonexin, functions to regulate Cl-flux by mediating calmodulin kinase II (CaMKII) activity and Annexin V has been shown to regulate PKC activity. Annexin V is ubiquitously expressed at high levels in tissues and cells grown in tissue culture, while Annexin VIII exhibits a more limited distribution. Where co-expressed in the same tissues, Annexin VIII is often expressed at a 100-fold lower level than Annexin V. However, Annexin VIII is preferentially expressed in acute promyelocytic leukemia (APL) cells, which may relate to its role in hematopoietic cell differentiation. |
Product |
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 |
Purification And Purity |
ProA affinity purified |
Storage And Stability |
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles. |
Specificity |
Annexin V polyclonal antibody detects endogenous levels of Annexin V protein. |
BiowMW |
36 kDa |
Note |
For research use only, not for use in diagnostic procedure. |
Immunogen |
recombinant protein |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.