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Histone H3 polyclonal antibody

Histone H3 polyclonal antibody

Manufacturer	Bioworld Technology, Inc
Category	Antibodies Immunohistochemistry Western Blot Immunofluorescence Immunocytochemistry Primary Antibodies CHiP
Type	Antibody Primary
Specific against	Human, Mouse, Rat
Applications	WB, IF, IHC, ICC, CHIP
Amount	50ul
Host	Rabbit
Item no.	BS90642-50
Targets	H3C1
eClass 6.1	32160702
eClass 9.0	32160702
Available
Swiss-Prot	P68431(Human) P84243(Human) Q16695(Human) Q6NXT2(Human) Q71DI3(Human) P68433(Mouse) P84228(Mouse) Q6LED0(Rat)
Application_all	WB:1:1, 000-1:2, 000 ICC:1:50-1:200 IHC:1:100-1:500
Background	In eukaryotes, DNA is wrapped around histone octamers to form the basic unit of chromatin structure. The octamer is composed of histones H2A, H2B, H3 and H4, and it associates with approximately 200 base pairs of DNA to form the nucleosome. The association of DNA with histones results in dense packing of chromatin, which restricts proteins involved in gene transcription from binding to DNA. p300 preferentially acetylates Histone H3 at lysines 14 and 18 and Histone H4 at lysines 5 and 8. PCAF in its native form, primarily acetylates Histone H3 at lysine 14 to a monoacetylated form, and less efficiently acetylates Histone H4 at lysine 8. Histone H4 may also be acetylated at lysines 12 and 16, and the involvement of acetylated H4 with Histones H2A, H2B and H3 suggests that acetylated histones may be involved in dynamic chromatin remodeling.
Product	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification And Purity	ProA affinity purified
Storage And Stability	Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Specificity	Histone H3 polyclonal antibody detects endogenous levels of Histone H3 protein.
BiowMW	15 kDa
Note	For research use only, not for use in diagnostic procedure.
Immunogen	recombinant protein

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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