Comparison

LC3B polyclonal antibody

Manufacturer Bioworld Technology, Inc
Category
Type Antibody Primary
Specific against Human, Mouse, Rat
Applications WB, IP
Amount 100ul
Host Rabbit
Item no. BS90791-100
Targets MAP1A;;MAP1LC3A
eClass 6.1 32160702
eClass 9.0 32160702
Available
Swiss-Prot
Q9GZQ8(Human) Q9CQV6(Mouse) Q62625(Rat)
Application_all
WB:1:1, 000-1:2, 000
Background
Microtubule-associated proteins (MAPs) regulate microtubule stability and play critical roles in neuronal development and in maintaining the balance between neuronal plasticity and rigidity. MAP-light chain 3 beta (MAP-LC3beta) and MAP-light chain 3 alpha (MAP-LC3alpha) are subunits of both MAP1A and MAP1B. MAP-LC3beta, a homolog of Apg8p, is essential for autophagy and associated to the autophagosome membranes after processing. Two forms of LC3beta, the cytosolic LC3-I and the membrane-bound LC3-II, are produced post-translationally. LC3-I is formed by the removal of the C-terminal 22 amino acids from newly synthesized LC3beta, followed by the conversion of a fraction of LC3-I into LC3-II. LC3 enhances fibronectin mRNA translation in ductus arteriosus cells through association with 60S ribosomes and binding to an AU-rich element in the 3? untranslated region of fibronectin mRNA. This facilitates sorting of fibronectin mRNA onto rough endoplasmic reticulum and translation. MAP LC3beta may also be involved in formation of autophagosomal vacuoles. It is expressed primarily in heart, testis, brain and skeletal muscle.
Product
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification And Purity
ProA affinity purified
Storage And Stability
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Specificity
LC3B polyclonal antibody detects endogenous levels of LC3B protein.
BiowMW
14 kDa
Note
For research use only, not for use in diagnostic procedure.
Immunogen
recombinant protein

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100ul
Available: In stock
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