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p95 NBS1 polyclonal antibody

p95 NBS1 polyclonal antibody

Manufacturer	Bioworld Technology, Inc
Category	Antibodies Flow Cytometry Immunohistochemistry Immunoprecipitation Western Blot Immunofluorescence Immunocytochemistry Primary Antibodies CHiP
Type	Antibody Primary
Specific against	Human, Mouse, Rat
Applications	WB, FC, IF, IP, IHC, ICC, CHIP
Amount	50ul
Host	Rabbit
Item no.	BS91011-50
Targets	NBN
eClass 6.1	32160702
eClass 9.0	32160702
Available
Swiss-Prot	O60934(Human) Q9R207(Mouse) Q9JIL9(Rat)
Application_all	WB:1:1, 000 ICC:1:50-1:200 FC:1:50-1:100 IHC:1:50
Background	DNA repair proteins are necessary for the maintenance of chromosome integrity and are involved in the elimination of premutagenic lesions from DNA. The DNA repair proteins Rad51 and Rad52 are key components of the double-strand-break repair (DSBR) pathway. Rad51 is essential for mitotic and meiotic recombination, and its mutation in yeast and mammalian cells results in chromosome loss. Overexpression of Rad52 confers resistance to ionizing radiation and induces homologous intrachromosomal recombination. Rad52 is thought to be involved in an early stage of Rad51-mediated recombination. Additional proteins involved in the pathway include Dmc1 and nibrin. Dmc1 is specifically involved in meiotic recombination. Nibrin, which complexes with Mre11 and Rad50, is absent in Nijemegen breakage syndrome (NBS) patients.
Product	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification And Purity	ProA affinity purified
Storage And Stability	Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Specificity	p95 NBS1 polyclonal antibody detects endogenous levels of p95 NBS1 protein.
BiowMW	95 kDa
Note	For research use only, not for use in diagnostic procedure.
Immunogen	recombinant protein

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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