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TrkA polyclonal antibody

TrkA polyclonal antibody

Manufacturer	Bioworld Technology, Inc
Category	Neuroscience Neural Lineage Markers Metabolism Diabetes Molecular Targets for Neuroscience Targets for Rodent Neurosciences Neural Signaling Antibodies Cell Biology Cell Status Necrosis Cytoskeleton Flow Cytometry Immunohistochemistry Western Blot Immunocytochemistry Motor proteins Primary Antibodies Microfilaments
Type	Antibody Primary
Specific against	Human, Mouse, Rat
Applications	WB, FC, IHC, ICC
Amount	100ul
Host	Rabbit
Item no.	BS91374-100
Targets	NGF ;;MYH14;;NGFR;;NTRK1;;SRCIN1
eClass 6.1	32160702
eClass 9.0	32160702
Available
Swiss-Prot	P04629(Human) Q3UFB7(Mouse) P35739(Rat)
Application_all	WB:1:500 ICC:1:100 IHC:1:50-1:200 FC:1:50-1:100
Background	The Trk proto-oncogene encodes a tyrosine protein kinase, Trk A, also designated Trk gp140, that serves as a receptor for certain neurotrophic factors including nerve growth factor (NGF) and neurotrophin-3 (NT-3). Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on Tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3. Thus it appears that Trk B gp145 may represent a neurotrophic receptor for BDNF and NT-3. The third member of the Trk family of tyrosine kinases, Trk C, encodes a protein designated Trk C gp145 that is preferentially expressed in brain tissue, is equally related to Trk A and Trk B and is a functional receptor for NT-3.
Product	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification And Purity	Protein affinity purified.
Storage And Stability	Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Specificity	TrkA polyclonal antibody detects endogenous levels of TrkA protein.
BiowMW	Predicted band size 87 kDa
Note	For research use only, not for use in diagnostic procedure.
Immunogen	Recombinant protein

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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