Cathepsin A 20k (M327) polyclonal antibody

P10619

The cathepsin family of proteolytic enzymes include several diverse classes of proteases. Cathepsins B, L, H, K, S and O comprise the cysteine protease class. Cathepsins D and E comprise the aspartyle protease class. The serine protease class includes cathepsin G. Cathepsins function in cellular metabolism and participate in peptide biosynthesis and protein degradation. Cathepsin A, a serine carboxypepidase, exists in a high molecular weight lysosomal complex with beta-galactosidase (beta-Gal) and alpha-neuraminidase (Neu1). Cathepsin A functions to protect beta-Gal and Neu1 from intralysosomal proteolysis. Deficiencies in cathepsin A lead to deficiencies in beta-Gal and Neu1. The gene encoding human cathepsin A maps to chromosome 20q13.12. Mutations in this gene cause glactosialidosis, a lysosomal storage disorder resulting from the beta-Gal and Neu1 deficiencies.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Cathepsin A 20k (M327) polyclonal antibody detects endogenous levels of Cathepsin A 20k protein.

For research use only, not for use in diagnostic procedure.