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c-Myb (Phospho-S11) polyclonal antibody

c-Myb (Phospho-S11) polyclonal antibody

Manufacturer	Bioworld Technology, Inc
Category	Antibodies Flow Cytometry Immunohistochemistry Western Blot Immunofluorescence Immunocytochemistry Primary Antibodies
Type	Antibody Primary
Specific against	Human
Applications	WB, FC, IF, IHC, ICC
Amount	100ul
Host	Rabbit
Item no.	BS94005-100
Targets	MYB
eClass 6.1	32160702
eClass 9.0	32160702
Available
Swiss-Prot	P10242(Human)
Application_all	WB:1:1, 000-1:2, 000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100
Background	The Myb family of transcription factors regulates proliferation, differentiation and apoptosis of hematopoletic cells. The avian myeloblastosis viral (v-Myb) protein is nuclear and binds to specific DNA sequences. The gene encoding for v-Myb is oncogenic, causing monoblastic leukemia and transforming myelomonocytic cells by deregulating the expression of specific target genes. v-Myb functions as a transcriptional activator, and it can repress biologically relevant genes such as Ets-2, which promotes macrophage differentiation. The proto-oncogene c-Myb encodes for a nuclear protein that plays a role in transcriptional regulation and may be essential for hematopoietic cell proliferation. A-Myb is also member of the Myb family that is expressed in proliferating B cell centroblasts. Transgenic mice overexpressing A-Myb posses enhanced hyperplasia of the lymph nodes.
Product	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification And Purity	ProA affinity purified
Storage And Stability	Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Specificity	c-Myb (Phospho-S11) polyclonal antibody detects endogenous levels of c-Myb protein only when phosphorylated at S11.
BiowMW	72/75 kDa
Note	For research use only, not for use in diagnostic procedure.
Immunogen	Synthetic phospho-peptide corresponding to residues surrounding Ser11 of human V-Myb+C-Myb.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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