Claudin-3(Phospho Tyr219) Polyclonal Antibody

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets| forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet| with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene| a member of the claudin family| is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin| and shares aa sequence similarity with a putative apoptosis-related protein found in rat.

1 mg/ml

23319

-20°C for 1 year