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ERBB2 Monoclonal Antibody

ERBB2 Monoclonal Antibody

Item no.	CSB-MA172796
Manufacturer	Cusabio
Amount	100 ul
Category	Oncology Neuroscience Neural Lineage Markers Neural Signaling Neural Adhesion Molecules Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Cell Biology Cell Culture Cytokines Adenocarcinoma Immunohistochemistry Western Blot ELISA Primary Antibodies Astrocytoma By Organ Lung Cancer Bladder Cancer Colorectal Cancer Breast Cancer Calcium Binding Protein Markers
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, IHC, ELISA
Clone	24D11
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1
Conjugate/Tag	Unconjugated
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	C-erbB-2, EC 2.7.10.1, Epidermal growth factor receptor-related protein, ErbB2, HER2, MLN 19, NEU, NEU proto-oncogene, NGL, Receptor protein-tyrosine kinase erbB-2, Receptor protein-tyrosine kinase erbB-2 precursor, Tyrosine kinase-type cell surface recep
Similar products	C-erbB-2, NEU proto-oncogene, MLN 19, HER2, NEU, NGL, Epidermal growth factor receptor-related protein, ErbB2, EC 2.7.10.1, Receptor protein-tyrosine kinase erbB-2, Receptor protein-tyrosine kinase erbB-2 precursor, Tyrosine kinase-type cell surface recep
Available
Manufacturer - Type	Hybridoma Monoclonal Antibody
Manufacturer - Targets	ERBB2
Storage Conditions	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Manufacturer - Alias	C-erbB-2, EC 2.7.10.1, Epidermal growth factor receptor-related protein, ErbB2, HER2, MLN 19, NEU, NEU proto-oncogene, NGL, Receptor protein-tyrosine kinase erbB-2, Receptor protein-tyrosine kinase erbB-2 precursor, Tyrosine kinase-type cell surface recep
Immunogen Species	Human
Immunogen	Purified recombinant fragment of human Her2 expressed in E. Coli
Dilution	WB:1:500-1:5000, IHC:1:50-1:500
Buffer	Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method	Affinity-chromatography
General Research Areas	Tags & Cell Markers
Initial Research Areas	Tags & Cell Markers
Relevance	This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
Antigen Species	Human
Antigen	Purified recombinant fragment of human Her2 expressed in E. Coli
Clonality	Monoclonal

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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Delivery expected until 8/14/2025

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