TGFBR1 Antibody, HRP conjugated

Item no.	CSB-PA023451LB01HU-50ug
Manufacturer	Cusabio
Amount	50 ug
Quantity options	100 ug 50 ug
Category	Oncology Neuroscience Neuroinflammation Neural Signaling Antibodies By Cell Type Carcinoma Glioma Cell Biology Cell Culture Cytokines Mesothelioma ELISA Primary Antibodies By Organ Colorectal Cancer Immunostaining
Type	Antibody Polyclonal
Format	Liquid
Applications	ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	HRP
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	AAT 5 antibody,AAT5 antibody,Activin A receptor type II like kinase 53kDa antibody,Activin A receptor type II like kinase antibody,Activin A receptor type II like kinase,53kD antibody,Activin A receptor type II like protein kinase of 53kD antibody,activin A receptor type II-like kinase,53kDa antibody,activin A receptor type II-like protein kinase of 53kD antibody,Activin receptor like kinase 5 antibody,Activin receptor-like kinase 5 antibody,ACVRLK 4 antibody,ACVRLK4 antibody,ALK 5 antibody,ALK-5 antibody,ALK5 antibody,LDS1A antibody,LDS2A antibody,MSSE antibody,Serine/threonine protein kinase receptor R4 antibody,Serine/threonine-protein kinase receptor R4 antibody,SKR 4 antibody,SKR4 antibody,TbetaR I antibody,TbetaR-I antibody,TGF beta receptor type 1 antibody,TGF beta receptor type I antibody,TGF beta type I receptor antibody,TGF-beta receptor type I antibody,TGF-beta receptor type-1 antibody,TGF-beta type I receptor antibody,TGFBR 1 antibody,TGFBR1 antibody,TGFBR1 protein antibody,TGFR 1 antibody,TGFR-1 antibody,TGFR1 antibody,TGFR1_HUMAN antibody,Transforming growth factor beta receptor 1 antibody,Transforming growth factor beta receptor I (activin A receptor type II like kinase,53kD) antibody,Transforming growth factor beta receptor I antibody,transforming growth factor,beta receptor 1 antibody,transforming growth factor,beta receptor I (activin A receptor type II-like kinase,53kD) antibody,Transforming growth factor-beta receptor type I antibody
Similar products	TGFBR1, ALK5 SKR4, TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Targets	TGFBR1
Storage Conditions	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Manufacturer - Alias	AAT 5 antibody, AAT5 antibody, Activin A receptor type II like kinase 53kDa antibody, Activin A receptor type II like kinase antibody, Activin A receptor type II like kinase, 53kD antibody, Activin A receptor type II like protein kinase of 53kD antibody, activin A receptor type II-like kinase, 53kDa antibody, activin A receptor type II-like protein kinase of 53kD antibody, Activin receptor like kinase 5 antibody, Activin receptor-like kinase 5 antibody, ACVRLK 4 antibody, ACVRLK4 antibody, ALK 5 antibody, ALK-5 antibody, ALK5 antibody, LDS1A antibody, LDS2A antibody, MSSE antibody, Serine/threonine protein kinase receptor R4 antibody, Serine/threonine-protein kinase receptor R4 antibody, SKR 4 antibody, SKR4 antibody, TbetaR I antibody, TbetaR-I antibody, TGF beta receptor type 1 antibody, TGF beta receptor type I antibody, TGF beta type I receptor antibody, TGF-beta receptor type I antibody, TGF-beta receptor type-1 antibody, TGF-beta type I receptor antibody, TGFBR 1 antibody, TGFBR1 antibody, TGFBR1 protein antibody, TGFR 1 antibody, TGFR-1 antibody, TGFR1 antibody, TGFR1_HUMAN antibody, Transforming growth factor beta receptor 1 antibody, Transforming growth factor beta receptor I (activin A receptor type II like kinase, 53kD) antibody, Transforming growth factor beta receptor I antibody, transforming growth factor, beta receptor 1 antibody, transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD) antibody, Transforming growth factor-beta receptor type I antibody
Immunogen Species	Human
Immunogen	Recombinant Human TGF-beta receptor type-1 protein (157-244AA)
Background	Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation.
Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method	>95%, Protein G purified
General Research Areas	Cardiovascular
Initial Research Areas	Cardiovascular
Antigen Species	Human
Antigen	Recombinant Human TGF-beta receptor type-1 protein (157-244AA)
Clonality	Polyclonal

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ug

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Delivery expected until 12/18/2025

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