EPHA3 (Ab-602) Antibody

Polyclonal Antibody

EPHA3

AW492086 antibody, Cek4 antibody, EC 2.7.10.1 antibody, EK4 antibody, End3 antibody, Eph receptor A3 antibody, EPH-like kinase 4 antibody, EPH-like tyrosine kinase 1 antibody, EPHA3 antibody, EPHA3_HUMAN antibody, Ephrin receptor EphA3 antibody, Ephrin type-A receptor 3 antibody, ETK 1 antibody, ETK antibody, ETK1 antibody, HEK 4 antibody, HEK antibody, HEK4 antibody, Human embryo kinase 1 antibody, Human embryo kinase antibody, Mek4 antibody, MGC109882 antibody, Receptor tyrosine kinase HEK antibody, Testicular tissue protein Li 64 antibody, Tyro 4 antibody, Tyro4 antibody, TYRO4 protein tyrosine kinase antibody, Tyrosine protein kinase receptor ETK 1 antibody, Tyrosine-protein kinase receptor ETK1 antibody, Tyrosine-protein kinase TYRO4 antibody

Synthesized peptide derived from Internal of human EPHA3.

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.

Wicks I.P., Proc. Natl. Acad. Sci. U.S.A. 89:1611-1615(1992).
Chiari R., Cancer Res. 60:4855-4863(2000).
Boyd A.W., J. Biol. Chem. 267:3262-3267(1992).

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Cardiovascular

Synthesized peptide derived from Internal of Human EPHA3.