PAWR Antibody

PAWR

2310001G03Rik antibody; PAR 4 antibody; PAR-4 antibody; Pawr antibody; PAWR_HUMAN antibody; PRKC Apoptosis WT1 Regulator antibody; PRKC apoptosis WT1 regulator protein antibody; Prostate apoptosis response 4 protein antibody; Prostate apoptosis response protein 4 antibody; prostate apoptosis response protein PAR-4 antibody; Transcriptional repressor Par-4-like protein PAWR antibody; Transcriptional repressor PAR4 antibody; WT1 Interacting Protein antibody

Synthesized peptide derived from human prostate apoptosis response protein-4.

Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.

Hongzhe Li, J. Biol. Chem., Feb 2007, 282: 4943 - 4950.
Wuhan Xiao, Cancer Res., Aug 2003, 63: 4698 - 4704.
Thierry Virolle, J. Biol. Chem., Mar 2003, 278: 11802 - 11810.
Derek J. Richard, Genes & Dev., Feb 2001, 15: 328.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Cell Biology

Synthesized peptide derived from Human prostate apoptosis response protein-4.