RFWD3 Antibody

RFWD3

BC027246 antibody; E3 ubiquitin protein ligase RFWD3 antibody; E3 ubiquitin-protein ligase RFWD3 antibody; FLJ10520 antibody; MGC27888 antibody; RFWD3 antibody; RFWD3_HUMAN antibody; Ring finger and WD repeat domain 3 antibody; RING finger and WD repeat domain containing protein 3 antibody; RING finger and WD repeat domain-containing protein 3 antibody; RING finger protein 201 antibody; RNF201 antibody

Synthesized peptide derived from internal of human RFWD3.

E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair.

The MGC Project Team, Genome Res. 14:2121-2127(2004).
Ota T., Nat. Genet. 36:40-45(2004).
Matsuoka S., Science 316:1160-1166(2007).

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Human

Polyclonal