PRKAG1 Antibody

Polyclonal Antibody

PRKAG1

5' AMP activated protein kinase gamma 1 subunit antibody, 5' AMP activated protein kinase subunit gamma 1 antibody, 5''-AMP-activated protein kinase subunit gamma-1 antibody, AAKG1_HUMAN antibody, AMP activated protein kinase noncatalytic gamma 1 subunit antibody, AMPK gamma 1 chain antibody, AMPK gamma1 antibody, AMPK subunit gamma-1 antibody, AMPKg antibody, MGC8666 antibody, PRKAG 1 antibody, PRKAG1 antibody, Protein kinase AMP activated gamma 1 non catalytic subunit antibody, protein kinase, AMP-activated, noncatalytic gamma-1 antibody

Synthesized peptide derived from internal of human PRKAG1/2/3.

AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton, probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.

Gao G., J. Biol. Chem. 271:8675-8681(1996).
The MGC Project Team, Genome Res. 14:2121-2127(2004).
Baba M., Proc. Natl. Acad. Sci. U.S.A. 103:15552-15557(2006).

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Cardiovascular

Synthesized peptide derived from internal of Human PRKAG1/2/3.