EIF4EBP1 (Ab-36) Antibody

EIF4EBP1

4E-BP1 antibody; 4EBP1 antibody; 4EBP1_HUMAN antibody; BP 1 antibody; eIF4E binding protein 1 antibody; eIF4E-binding protein 1 antibody; Eif4ebp1 antibody; Eukaryotic translation initiation factor 4E-binding protein 1 antibody; PHAS-I antibody; PHASI antibody; Phosphorylated heat- and acid-stable protein regulated by insulin 1 antibody

Peptide sequence around aa.34ca.38 (S-T-T-P-G) derived from Human 4E-BP1.

4E-BP1 encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.

Gingras AC, et al. Genes Dev Nov. 2005 Feb 15.
Mothe-Satney I, et al.(2000) J Biol Chem:15(21): 2852-64.
Gingras AC, et al. (1999) Genes Dev:13(11): 1422-37.
Lal L, et al.(2005) Blood, 105(4): 1669-7.

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugateds. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Epigenetics and Nuclear Signaling

Peptide sequence around aa.34~38 (S-T-T-P-G) derived from Human 4E-BP1.