Phospho-PIK3R1 (Tyr607) Antibody

Polyclonal Antibody

PIK3R1

GRB1 antibody, p85 alpha antibody, p85 antibody, P85A_HUMAN antibody, Phosphatidylinositol 3 kinase associated p 85 alpha antibody, Phosphatidylinositol 3 kinase regulatory 1 antibody, Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 1 (p85 alpha) antibody, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha antibody, Phosphatidylinositol 3-kinase regulatory subunit alpha antibody, Phosphoinositide 3 kinase, regulatory subunit 1 (alpha) antibody, PI3 kinase p85 antibody, PI3 kinase p85 subunit alpha antibody, PI3-kinase regulatory subunit alpha antibody, PI3-kinase subunit p85-alpha antibody, PI3K antibody, PI3K p85 antibody, PI3K regulatory subunit alpha antibody, Pik3r1 antibody, PtdIns 3 kinase p85 alpha antibody, PtdIns-3-kinase regulatory subunit alpha antibody, PtdIns-3-kinase regulatory subunit p85-alpha antibody

Peptide sequence around phosphorylation site of Tyrosine 607(D-Q-Y(p)-S-L) derived from Human PI3-kinase p85-alpha.

Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling.

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Signal Transduction

Peptide sequence around phosphorylation site of Tyrosine 607(D-Q-Y(p)-S-L) derived from Human PI3-kinase p85-alpha.